John A T Young Selected Research

Avian Sarcoma

1/2011	Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion.
1/2007	The hr1 and fusion peptide regions of the subgroup B avian sarcoma and leukosis virus envelope glycoprotein influence low pH-dependent membrane fusion.
10/2005	Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication.
7/2005	Avian sarcoma and leukosis virus cytopathic effect in the absence of TVB death domain signaling.
6/2005	Imaging individual retroviral fusion events: from hemifusion to pore formation and growth.
10/2004	Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral uncoating.
6/2004	Effects of lipid rafts on dynamics of retroviral entry and trafficking: Quantitative analysis.
1/2004	Amino acid residues Tyr-67, Asn-72, and Asp-73 of the TVB receptor are important for subgroup E avian sarcoma and leukosis virus interaction.
2/2003	Two retroviral entry pathways distinguished by lipid raft association of the viral receptor and differences in viral infectivity.
8/2002	Resistance to infection by subgroups B, D, and E avian sarcoma and leukosis viruses is explained by a premature stop codon within a resistance allele of the tvb receptor gene.

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John A T Young Research Topics

Disease

23	Infections 12/2022 - 01/2002
12	Avian Sarcoma 01/2011 - 01/2002
10	Neoplasms (Cancer) 08/2010 - 01/2002
9	Anthrax 01/2012 - 02/2003
5	HIV Infections (HIV Infection) 01/2017 - 03/2011
3	Chronic Hepatitis B 01/2022 - 01/2018
2	Virus Diseases (Viral Diseases) 01/2014 - 10/2011
2	Edema (Dropsy) 04/2004 - 01/2003
1	Inflammation (Inflammations) 01/2022
1	Hepatitis B 01/2021
1	COVID-19 11/2020
1	Hepatocellular Carcinoma (Hepatoma) 06/2018
1	Viremia 01/2018
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2018
1	Fibrosis (Cirrhosis) 01/2012
1	Schizophrenia (Dementia Praecox) 09/2010
1	Ataxia (Dyssynergia) 08/2010
1	Acquired Immunodeficiency Syndrome (AIDS) 11/2008
1	Carcinoma (Carcinomatosis) 03/2008
1	Inhalation anthrax 09/2005
1	Superinfection 07/2005
1	Shock 12/2003
1	Sudden Death 12/2003
1	Sarcoma (Soft Tissue Sarcoma) 06/2002
1	Avian Leukosis 06/2002

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 12/2022 - 01/2002
6	anthrax toxin (anthrax lethal factor)IBA 03/2008 - 02/2003
5	Small Interfering RNA (siRNA)IBA 01/2020 - 08/2010
5	AntigensIBA 01/2018 - 04/2003
5	Glycoproteins (Glycoprotein)IBA 10/2011 - 10/2004
5	anthrax toxin receptorsIBA 09/2005 - 02/2003
4	Antiviral Agents (Antivirals)IBA 01/2021 - 05/2015
4	AntitoxinsIBA 10/2007 - 02/2003
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 10/2004
3	Tva receptorIBA 01/2011 - 06/2004
3	Peptides (Polypeptides)IBA 01/2007 - 06/2002
3	Amino Acids FDA Link 04/2004 - 06/2002
2	EnzymesIBA 01/2022 - 02/2016
2	entecavir FDA Link 06/2020 - 01/2018
2	Hepatitis B e AntigensIBA 01/2019 - 06/2018
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 06/2018 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2017 - 08/2013
2	LigandsIBA 08/2013 - 01/2002
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 07/2005 - 06/2002
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 07/2005 - 06/2002
2	Cell Surface ReceptorsIBA 10/2004 - 02/2003
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2022
1	Aurora KinasesIBA 12/2022
1	CytokinesIBA 01/2022
1	Toll-Like Receptor 7IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2021
1	InterferonsIBA 06/2020
1	Immunologic Factors (Immunomodulators)IBA 01/2019
1	Viral AntigensIBA 06/2018
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2018
1	Viral ProteinsIBA 01/2018
1	ChemokinesIBA 01/2017
1	Actin Depolymerizing Factors (Cofilins)IBA 01/2017
1	SulfotransferasesIBA 02/2016
1	Deubiquitinating Enzyme CYLDIBA 07/2014
1	Deubiquitinating EnzymesIBA 07/2014
1	LuciferasesIBA 05/2014
1	AntibodiesIBA 08/2013
1	Therapeutic UsesIBA 01/2012
1	Conditioned Culture MediaIBA 01/2012
1	beta-Arrestin 1IBA 10/2011
1	ClathrinIBA 10/2011
1	ran-binding protein 2IBA 03/2011
1	Karyopherins (Importin)IBA 03/2011
1	Protein Isoforms (Isoforms)IBA 01/2011
1	NeuregulinsIBA 09/2010
1	Transcription Factors (Transcription Factor)IBA 08/2010
1	Biological ProductsIBA 11/2008
1	Neutralizing AntibodiesIBA 10/2007
1	Indicators and Reagents (Reagents)IBA 10/2007
1	VaccinesIBA 10/2007
1	Viral DNAIBA 07/2005
1	TNF-Related Apoptosis-Inducing LigandIBA 07/2005
1	LipidsIBA 06/2004
1	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 06/2004
1	MetalsIBA 04/2004
1	Virulence Factors (Pathogenicity Factors)IBA 02/2003
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2003
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2003
1	Nonsense Codon (Nonsense Mutation)IBA 08/2002
1	NF-kappa B (NF-kB)IBA 06/2002
1	Immunoglobulins (Immunoglobulin)IBA 06/2002
1	Neuregulin-1 (Neuregulin 1)IBA 01/2002

Therapy/Procedure

6	Therapeutics 11/2020 - 07/2005